The major glycoprotein of the varicella-zoster virus is called gE. Previous research has shown tht human antibodies against gE have a relatively broader staining pattern seen by confocal microscopy than the mouse monoclonal antibody against gE in VZV-32 (wild type) infected melanoma cells. To further investigate these findings, melanoma cells infected with the Varicella-Zoster virus wild type were treated with 370 and 3B3, two mouse primary monoclonal antibodies against gE, and Human gE, also a primary monoclonal antibody against gE. Upon treatment with the antibodies the cells were then stained with fluorescent antibodies. As seen by confocal microscopy images, the infected cells stained against gE with 370 had more of a restricted staining pattern relative to the cells stained against gE with the human monoclonal antibody. These results suggested that MAb370 stained against gE when it was present mainly in the Golgi, a site of glycoprotein synthesis.