Garry Buettner, PhD
Redox Biology: The balance of free radicals and antioxidants
Research Interests
Quantitative Redox Biology - This research effort has as a goal to arrive at quantitative measurements, and quantitative approaches to understand how the redox environment of cells and tissues dictate their fundamental biology.
The fundamental chemistry and biochemistry of vitamins C and E and related antioxidants.
The use of vitamin C (ascorbate) in the treatment of cancer.
The use of the ascorbate radical as a marker for free radical oxidative stress. This research has provided the foundation for many ongoing free radical-related research projects here at Iowa and around the world.
The role of metals in free radical oxidations. This has been a long time area of research. We were the first to demonstrate that adventitious iron can change the results observed in free radical experiments and that chelating agents could be used to modulate the catalytic activity of metals.
At least one year of college chemistry, biology and mathematics.
Analytical chemistry approaches are used to determine the antioxant profile of cells and tissues. Mathematical approaches are used to simulate the redox networks in cells.
