Matthew Potthoff, PhD
Functional characterization of novel regulators of hepatic metabolism
Obesity and insulin resistance are major contributors to the epidemic of metabolic diseases including dyslipidemia, hypertension and type 2 diabetes. The latest projections estimate that there will be 2.16 billion overweight and 1.12 billion obese individuals globally by 2030. As such, there is an urgent need for the generation of new insulin sensitizers. My research is focused on the physiological mechanisms that regulate metabolic homeostasis and insulin sensitivity. We are specifically interested in unraveling hepatic pathways that govern systemic energy balance and glucose homeostasis in hopes of identifying a new therapeutic to treat obesity and metabolic disease. Utilizing novel transgenic mouse models, classical pharmacological methodologies, and state-of-the-art tracer techniques we have uncovered novel mechanisms regulating insulin sensitivity that could lead to new treatments for cardiovascular and metabolic disease.
Experience with molecular biology techniques (e.g., PCR).
We are interested in talented undergraduate students who are motivated and can work independently. The goal of the student's project will be to study the function of a novel gene predicted to regulate metabolic homeostasis. This project will require the student to learn new techniques and think critically about his/her research.
